November 22 2019 the ESNM Guidelines on functional constipation in adults has been published in Neurogastroenterology and Motility. These guidelines have been produced with the participation of different specialists across Europe involved in management of constipation.
The guideline provides evidence based practical algorithms for diagnosis and stepwise treatment of constipation in adults.
Implementation of the guideline should improve and harmonize management of constipation across different countries in Europe.
J. Serra, lead author
Click on the link to read full article https://doi.org/10.1111/nmo.13762
Click on image to see graphical summary
Find an interresting comment from Ger Clarke and Niall Hyland (Irish Society of Gastroenterology Neurogastroenterology representative) on the topic of how medication interacts with teh microbiome. A new study, presented at UEG, has revealed that 18 commonly used drug categories extensively affect the bacteria living in the gut. Eight different categories of drugs were also found to increase antimicrobial resistance mechanisms in study participants.
Click here to read full article
From 22-24th November 2019. more than 240 medical professionals (gastroenterologists, digestive surgeons, neurologists oncologists and nutrition specialists), pharmacists and psychologists from all over Croatia, Slovenia, Serbia, Bosnia and Herzegovina participated in the second Symposium of Probiotics in digestive medicine organized by Goran Hauser, ESNM SC member, and supported by local ( PharmaS, JGL, Abela) and international (Sandoz, Takeda, TEVA) companies. This event has been organised by Croatian Gastroenterology Society and Croatian Neurogastro&Motility Society and endorsed by ESNM
A rich and interesting program combining lectures, case studies, and State of the Art talks was presented to the audience. With important support from Daniel Pohl and Nyal Hyland ESNM SC members and other internationally renowned experts S. O’Mahony, G. Clark, M. Rajilić Stojanović, M. Kukla, G. Gorkiewicz… the programme gained a huge interest in the audience.
N. Hyland and colleagues from APC Microbiome Ireland talked about the microbiome and GI physiology, visceral hypersensitivity and Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. M. Rajilić Stojanović discussed a growing field of dietary influences and microbiota development.
Renowned hepatologists explained the influences of gut microbiota on the onset and exacerbation of hepatic encephalopathy, liver cirrhosis and portal hypertension. Interesting hepatology lecture tried to answer on eternal question, which was before in the Gut-liver axis liver disease: the chicken (liver cirrhosis) and the egg (dysbiosis) followed by an explanation of the microbial challenge in the hepatic encephalopathy.
A symposium was the opportunity to present a Croatian translation of the WGO Probiotic global guidelines. Moreover, a Croatian Pharmacologic society presented ad questionnaire and guidelines regarding the usage of probiotics for pharmacists.
The participating interdisciplinary audience and the active discussions during and after presentations allowed interesting exchanges about these currently very relevant topics in clinical care.
G. Hauser - December 2019
Since 2005, the Romanian Society of Neurogastroenterology organizes biennial congresses under the name of NeurogastRO, with international participation. This year the NeurogastRO 2019 meeting was held in Iasi, between 7th and 9th of November. It reunited both leading experts and young investigators actively involved in digestive motility and functional gastrointestinal disorders from Romania and Europe. It was a good opportunity to interact together with the 20 international guest speakers and to exchange high-level experience.
Hot topics like gut microbiota (Giovanni Barbara, Luminita Iancu), pain in neurogastroenterology (Qasim Aziz, Ahmed Albusoda), new diagnostic tools in Neurogastroenterology (Radu Tutuian, Jan Tack, Daniel Pohl), GERD (Edoardo Savarino), digestive endoscopy in Neurogastroenterology (Dana Dobru, Bas Weusten, Eugen Dumitru), Neurogastropharmacology (Monica Hancianu, Teodor Robu), neurogastroenterology in pediatrics (Dorin Farcau, Simona Gavrilescu) were included in the program. Special session with neurogastroenterology topics from Central and Eastern Europe organized by Dan Dumitrascu together with Agata Mulak and Goran Hauser from ESNM included important opinion leaders in the field and also young people from Albania, Belarus, Bulgaria, Croatia, Hungary, Macedonia, Moldova, Poland, Russia, Serbia, Ukraine, and of course, Romania. Local faculties presented also their research results and gave state-of the art lectures. Vasile Drug, the president of Romanian Society of Neurogastroenterology highlighted the present situation, proposals for better management of Romanian patients with neurogastroenterology and also proposals for multicenter studies and guidelines endorsed by the society.
The meeting was successful with more than 250 attendees. Participants had the opportunity to share experience and to design new directions. During this meeting, two hands-on courses on impedance-pHmetry and high-resolution manometry were also organized.
V. Drug, D. Dumitrascu, Co-presidents of NeurogastRO Iasi 2019 - December 2019
With great pleasure we share the latest news: a GENIEUR symposium was held at the neuroGASTRO2019 in Lisbon. Beate Niesler, Heidelberg (DE) reported on current collaborations within GENIEUR. Since 2016, 12 publications were generated: 4 reviews, 5 STSM based Original Articles and 3 Original Articles of collaborative projects were published from GENIEUR partners; 6 manuscripts are in preparation data of which were recently presented at national and international meetings. This is a remarkable achievement, especially, since for none of these studies funding has been available and people were doing this based no their intrinsic motivation.
Dan Dumitrascu from Cluj-Napoca (RO) gave an update on the new COST Action application European Network on cross-cultural differences in IBS. The COST Action proposal was rejected in May 2019 and re-submitted in early September 2019 - let’s keep our fingers crossed for a successful evaluation.
The GENIEUR initiated UEG LINK Award Project ‘Help EU in IBS’ in which groups from the Netherlands, Germany, Norway, Bosnia and Herzegovina, Serbia and Malta were engaged in the translation and validation of questionnaires of the GENIEUR deep phenotyping protocol, is currently wrapped up as a blueprint for others and will be submitted to the UEG Journal.
Regarding funding on EU level we can conclude, raising awareness about the bad funding situation in our Lancet G&H commentary in 2018 as well as being persistent paid off: we are happy to share that finally, the fifth H2020 proposal was accepted for funding and will kick-off in 2020 (coordinator is Javier Santos, Barcelona (ES)): DISCOvERIE (Development, dIagnosis and prevention of gender-related Somatic and metal COmorbidiTies in iRrItable bowel syndrome in Europe). Owing to this, GENIEUR was now picked for a success story by the COST program.
As you are aware, GENIEUR is doing lobbying for IBS research and increasing awareness about this devastating disorder. The GENIEUR leaflet in lay language (in 19 national languages) was distributed to GENIEUR members for lobbying.
We also produced a GENIEUR lobbying clip together with grasshopper kreativ with 18 subtitle versions. Our clip is available on the GENIEUR website. We would herewith like to THANK all of you who supported us in the translations be it for the patient leaflets or the subtitles of the video clip.
Since it is still tough to get funding for IBS research we decided to change gear and start to raise funds for our research via our website. Therefore, we implemented a donation button. Please spread the word and share the hyperlink to our website: www.GENIEUR.eu - Let’s see how that works out and make that fly!
The next GENIEUR Meeting will take place at the UEGW2020 in Amsterdam in October 2020.
B. Niesler and M. Simrén, Chair and Co-Chair of GENIEUR - December 2019
THANK YOU for making the NeuroGASTRO 2019, such an outstanding event!!!
Click here to watch a short review of our nuerogastroenterology and motility congress
I would like to highlight some of the milestones of Prof. Enck’s remarkable career. His main interests and focus in research are the brain-gut-axis in health and disease with focus on functional gastrointestinal disorders, gut microbiota, regulation of eating and food intake, the pathophysiology of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 180 original data paper in scientific, peer-reviewed journals, several book chapters and review articles. His seminal papers evaluating the role of the brain-gut-axis in functional bowel disorders are a tour de force in translational research. His work has continued to be highly cited and helped to advance the field not only of neurogastroenterology and motility or gastroenterology, but medicine at large.
Giovanni Barbara, President ESNM
We are very delighted to hand out the ESNM Lifetime Achievement Award to Vincenzo Stanghellini!
We are very pleased to congratulate all Award Winners: Javier Aguilera-Lizarraga (Best Asbtract Basic Science), Lisse Decraecker (Best Abstract Translational Science), Magdy El-Salhy (Best Abstract Clinical Science), Rubina Aktar, Maria Julieta Arguero,Nikita Hanning, Jasper Pannemans, Mafalda Sousa, Nathalie Stakenborg and Lucas Wauters!
We are very happy to announce that Jan Tack, long-time member of the ESNM Steering Committee, has been elected President of the Rome Foundationt. Congratulation! The Rome Foundation is an independent not for profit organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of functional gastrointestinal disorders (FGIDs). Our mission is to improve the lives of people with functional GI disorders.
Dr Niall Hyland at APC Microbiome Ireland SFI Research Centre, University College Cork, member of the ESNM Steering Committee, was awarded the €100, 000 global grant by Nature Research and Yakult, beating a field of nearly 200 international applicants.
Individuals respond to medications in different ways and it appears that each person’s microbiome may play a significant role in how drugs are absorbed and metabolized by the body. Recent research has shown that a person’s microbiome affects her/his response to chemotherapy and other medications e.g. for Parkinson’s Disease. As a pharmacologist, Dr Hyland is particularly interested in how the microbiome affects the ability of individuals to respond to anti-depressants and anti-psychotics.
“If depression has a knock-on effect on the microbiome and can generate gut-related disorders like Irritable Bowel Syndrome (IBS), how might depression affect the ability to process anti-depressant and anti-psychotic drugs?” said Dr Hyland, a senior lecturer in the Dept. of Physiology at UCC. “We will analyse the gut bacterial communities and enzymatic activities in patients with depression prior to treatment with medication and then analyse drug responses. We plan to use the pharmacokinetic results to build a computer model to predict how patients might respond to specific drugs based on the composition of their microbiomes. We hope that it will enhance the efficacy of treatment and increase patient compliance.”
Dr Hyland will work closely with colleagues at APC Microbiome Ireland, including Dr Gerard Clarke and Prof Ted Dinan in the Dept. of Psychiatry and Dr Brendan Griffin in the School of Pharmacy.
Last year an interesting Phase 2b study presented in DDW about a novel gastric-retentive Bile Acid Sequestrant (IW-3718). This year in DDW secondary end-points were presented. This drug is a slow-release tablet of colesevelam. This drug binds to bile acids which are refluxed into the stomach. Different doses of IW-3718 (500-1000-1500 mg) were given QD for 8 weeks and compared to placebo. All patients continued with PPI. Severity and frequency of GERD symptoms were improved especially with 1500 mg dose. Adverse event rates were 42-52% for IW-3718 and 41% for placebo. 10 patients were withdrew because of adverse events; 1.4-4.4% for IW-3718 and 4.3% for placebo.
Authors concluded that IW-3718 was efficacious in reducing of symptoms in PPI refractory GERD patients. IW-3718 was safe and well-tolerated at all doses.
Serhat Bor - July 2019
The Research Committee of the United European Gastroenterology (UEG) federation decided more than a year ago (Spring 2018) to conduct a survey among its 17 member societies about their demands for future research topic and areas. This survey was conducted over the summer of 2018, and the results are now presented in a paper published in the UEG Journal, with first author Paul Enck, representing ESNM in the UEG Research Committee. Take a look and see what all UEG member societies have in common when it comes to research ...
Congratulation to Javier Aguilera from Leuven, winning the best abstract in basic science, "Psychological Stress Triggers A Bystander Immune Response To Food Antigens Leading To Neuronal Hyperexcitability And Visceral Hypersensitivity"!
The abstract reads: In patients with Irritable Bowel Syndrome (IBS), psychological factors are associated with increased postprandial symptoms, albeit the underlying mechanisms remain unclear. In this study, we showed in mice that psychological stress can impair the establishment of oral tolerance to dietary antigens and lead to mast cell-induced visceral hypersensitivity upon antigen ingestion. This findings suggest that stress may play an important role in the mechanism of food-induced abdominal pain in IBS.
Congratulation to Lisse Decraecker winning the best abstract in translational science, "Activity-Based Profiling Of Secreted Peptidases In Irritable Bowel Syndrome".
The abstract reads:We investigated the serine peptidase activity in biopsy supernatants of IBS patients and healthy volunteers (HV) and showed an increase in trypsin-like, but not in chymotrypsin-like or elastase-like activity in a subgroup of IBS patients (1). This increase in trypsin-like activity was significantly inhibited by the protease-inhibitor UAMC-00050 (2), which has demonstrated efficacy in pre-clinical models of IBS. Therefore, our results add further support to the translational potential of UAMC-00050 to treat IBS. Additionally, by using this inhibitor as a scaffold, we will develop novel activity-based probes to identify the proteases underlying this increased proteolytic activity in IBS
Congratulation to Magdy El-Salhy winning the best abstract in clinical science, "Faecal Microbiota Transplantation (FMT) in IBS using a super-donor: A randomised, double-blind placebo-controlled study".
The abstract reads: A large, randomised, double-blind, placebo-controlled study have shown that faecal microbiota transplantation (FMT) using a single ‘super-donor’ is an effective and well tolerated treatment for irritable bowel syndrome (IBS), producing high rates of clinical response and marked symptom improvements.1 The study highlighted the importance of donor selection for optimising the effectiveness of FMT as a treatment for IBS.
On Saturday, August 24th 2019, more than 70 medical professionals (gastroenterologists, dieticians, surgeons and nutrition specialists) from all over Switzerland and abroad participated in the second SwissNGM Neurogastro Day, organized by PD Dr. Pohl, Treasurer SwissNGM, and supported by Lasermed, Permamed and Takeda.
A rich and interesting program combining lectures, case studies, tandem sessions and State of the Art talks was presented to the audience. Internationally renowned experts Prof. Witt talked about complementary medicine in functional gastrointestinal disorders; Prof. Aziz from London gave fascinating background knowledge and practical insights into “Gut-brain interactions” and Prof. Schmid discussed the growing field of allergies and food intolerances with all their overlaps, but also distinctions. Recently available motility techniques Endo- and EsoFLIP were presented by PD Dr. Pohl and illustrated in an interesting case study by L. Fischbach. Prof. Tutuian discussed the latest in GERD, inclusing procedural details of the Lyon classification, followed by a symposium run by Dr. Linas and PD. Dr. Borbély, presenting challenging case, where motility specialists and surgeons worked hand in hand to find solutions for complex patients.
The participating audience and the active discussions during and after presentations allowed interesting exchanges about these currently very relevant topics in clinical care. We are looking forward to our next motility course 2020!
Daniel Pohl - September 2019
With the aim to build successful collaborations, reinforcing the cross-talk between clinical and basic research, the 3rd nEUROgastro TANDEM Meeting succeeded also this year to create a European network of young investigators, eager to bring together a new set of valuable expertise to discover new knowledge in the Neurogastroenterology field.
Announced by the respective National NeuroGASTRO Societies, GENIEUR network and ESNM, the nEUROgastro TANDEM meeting 2019 was held at the Chronic Diseases Research Center (CEDOC) / NOVA Medical School, NOVA University of Lisbon, Portugal, from September 2 to 4.
Among the numerous applications received, twenty participants have been selected by the nEUROgastro TANDEM organizing Committee originating from 10 European countries and being at different career stage and levels of education. The choice was made among well-referenced and motivated applicants, with excellent track records, who were seeking to engage themselves in a brainstorming project that allowed boosting the interaction between one physician and one basic scientist working in Neurogastroenterology. Thus, ten MDs were paired up with ten PhD students, three months prior to the meeting. Each team was mentored by one member of the organizing committee, who advised them on how to compose a translational research project based on common interests and methodology available in their working environment.
The communication between each team member resulted in a 20-minute presentation of their study at the nEUROgastro TANDEM meeting 2019. Each project was then scored by all participants and organizing committee, according to a number of different criteria, including innovativeness, feasibility, methodology, budget, communication and teamwork. To note that 5,000 € was the maximum budget available for each project, which corresponded to the amount awarded, by ENMS, to the highest-evaluated research. It is important to remember that this price is intended as seed money and needs to be used by the winning team to collect the preliminary data necessary to apply to independent financial supports.
Although all projects were well composed, only the winning team had the opportunity to present a brief overview of the study, its impact, novelty and potential, during the TANDEM session taking place at the 3rd Meeting of the European Society of Neurogastroenterology and Motility - NeuroGASTRO 2019 - organized at Centro Cultural de Belém, in Lisbon, Portugal, from September 5 to 7 (http://www.neurogastro2019.org).
Thus, we would like to congratulate Mr. Lucas Wauters (MD) and Ms. Ana Pêgo (PhD student), for having joined forces towards the creation of a nEUROgastro investigation study, entitled: “Gut microbiota and iron metabolism in functional dyspepsia”. The clinical and fundamental questions of this research will be addressed in Lucas and Ana’s working countries, which are Belgium and Portugal, respectively, and highlighted in the upcoming issue of Nature Reviews Gastroenterology & Hepatology journal. Both students will also receive a 1-year free online subscription to Nature Reviews Gastroenterology & Hepatology and the invitation to attend the next European NeuroGASTRO Meeting - organized in Bucharest, Rumania, in September 2021 - where they will have the opportunity to present the data obtained.
Congratulations also to Ms. Anja Radovan (MD) and Mrs. Hanna Ilchmann-Diounou (PhD), working in Croatia and France, respectively, for their second-price-winning project entitled: “Does stress sensitize to acute pancreatitis?”, rewarded with a 1-year free online subscription to Nature Reviews Gastroenterology & Hepatology.
The nEUROgastro TANDEM organizing committee would like to acknowledge the participation of Dr. Annikka Polster and Prof. Magnus Simren as invited speaker to the meeting, thanking them for their interaction, kind availability and, especially, for being a role model of Neurogastro scientists to all of us.
Finally, we would like to acknowledge the sponsors, for allowing the nEUROgastro TANDEM meeting to reimburse all travel expenses to the participants and to provide accommodation during the meeting.
When interviewed through an anonymous survey, all MD and PhD students recognized the importance of this event for their scientific and personal development, pleasing also the local organizers for the social program that was put together.
Raffaella Gozzelino - September 2019
The 1st Tübingen based German Australian Psycho-Neuro-Gastroenterology Summer School is a collaborative initiative between Tübingen University and the Universities of Newcastle and Brisbane, Australia that are already closely connected with Eberhard Karls University Tübingen.
In the past, a research axis leading from Tübingen to Newcastle and Brisbane has been developed. With a focus on psychoneurogastroenterology that is an emerging research and clinical field in-between the disciplines of psychology/psychosomatic/psychiatry, neurology/neurosciences and gastroenterology. This field has no established curriculum in current medical teaching and training. It is facing increasing demand and attention from patients, doctors, and the public, as it covers a wide range of patients in need for adequate diagnosis and therapy. This requires scientific as well as clinical input from various subspecialties of medicine and beyond to provide a better understanding and management.
Basic and translational knowledge in pathophysiology, diagnostics and therapeutics in psycho-neuro-gastroenterology and its associated disorders are being taught as state-of-the-art lectures. Lectures were supplemented by in-depth insight during laboratory visits and seminars during one week from September 23-28, 2019. Seventeen international attendees from Germany, Portugal, Spain, Canada and Australia were selected to attend. Invited international speakers include Gerald Holtmann and Simon Keely from Australia and Fernando Azpiroz from Spain. Invited German experts in the field of psychoneurogastroenterology encompass Beate Niesler, Sigrid Elsenbruch, Bernd Löwe, Andreas Friebe and Antonius Schneider and from the Tübingen faculty Hubert Preissl, Matthias Willmann, Stephan Zipfel, Miriam Goebel-Stengel, Katrin Giel, Anne Herrmann-Werner, Kathrin Schag, Andreas Stengel, Peter Neckel, Nazar Mazurak and Paul Enck.
Social events included trainings in Swabian food. language and punt boating as well as visits to the Castle Hohentübingen as well as an excursion to Lake Constance.
This summer school was made possible by a grant from DAAD (Deutscher Akademischer Austauschdienst) and Dr. Schwabe GmbH. It was endorsed by ESNM.
The sequel of this summer school is planned in Australia for November 2020 so keep your eyes open for the call for applications!
Miriam Goebel-Stengel - September 2019
The Romanian Society of Gastroenterology and Hepatology organized between 6th and 8th of June 2019 the annual National Congress of Gastroenterology. During the meeting the Romanian Society of Gastroenterology organized a dedicated session on Neurogastroenterology. The program of the session included state of the art presentations and original papers on difficult achalasia, treatment in irritable bowel disease, dysbiosis, lactose intolerance, functional GI diseases in the elderly. During the postgraduate course held in conjunction with the meeting, neurogastro topics were also presented by national and international speakers. It included: bile acid diarrhea (Massimo Bellini – Italy) Intestinal Involvement in Ehlers-Danlos Syndrome (Gabrio Bassotti Italy), Psychogastroenterology (Dan Dumitrascu Romania).
Vasile Drug - June 2019
70 participants from different disciplines gathered at the meeting rooms of Evangelischer Diakonieverein Zehlendorf in Berlin at the occasion of the 26th annual meeting of the German Society of Neurogastronenterology and Motility (DGNM) from March 22 to 24, 2019. The meeting started on Friday afternoon with an informal dinner followed by a get‐together. Saturday morning Rainer Straub from Regensburg (D) gave a state of the art lecture on Neuroimmune connections ‐ an evolutionary and energy regulation stand point.
During this meeting, 38 talks were given in eight sessions. These were dedicated to basic science (ENS, mast cells, motility, inflammation and IBD, microbiome, pre‐ and probiotics, pancreas and pain) and clinical science (esophageal motility, IBD, eating disorders and IBS) and given by mainly youngsters who reported on their ongoing projects. A novum of the meeting was a dedicated session to discuss the future of German neurogastroenterology and strategies to generate young investigators in the field. Another highlight was the clinical lecture given by Jutta Keller from Hamburg on Diagnostics and Classificaton of gastric and intestinal motility disorders. She had received the DGVS Research Award of the Neurogastroenterology Foundation in 2018 and is one of the world’s leading experts in the field.
At the general assembly on Saturday evening, members of the society were updated on the activities of the national and international societies, including progress reports on GENIEUR, nEUROgastro TANDEM 2017, LBBB 2018 and ongoing ESNM activities. Robert Patejdl from Rostock received the annual award for the best neurogastro microscope picture taken. Anna Filzmayer from TiHo Hannover was awarded with the Martin Wienbeck Travel Stipend. Young basic researchers were encouraged by Michael Schemann to put more effort in building neurogastro scientific networks. Beate Niesler was re‐elected as German ESNM delegate. The evening ended with a get‐together party at the Italian restaurant next‐door.
The Sunday lectures were met with great interest. The meeting was concluded with a common lunch. The next meeting will take place in Freising at Pallotti‐Haus on February 28 to March 1, 2020.
Over the day 2 course neurogastroenterology experts from UK and Europe delegates gave delegates a problem based approach to manage the whole range of functional upper and lower GI symptoms. This included sessions on upper and lower GI physiology tests, when to request them and how to interpret them. There were additional sessions on the role of diet (Professor Whelan) , microbiota (Professor Cryan ) , neuromodulators and psychotherapy (Professor Van Oudenhove) and surgery (Professor Knowles) in Functional GI disorders. Delegates also got involved in communication skills stations where they had an opportunity to practice difficult communication scenarios with actors, under supervision of a Neurogastro expert. The course was extremely well received with excellent feedback and requests that this be held on a regular basis.
A hands-on course for gastrointestinal manometry and functional investigations was held between 31 March to 02 April 2019 at Cluj-Napoca, Romania. A total of 20 participants from Europe but also from Asia, Africa, and South America attended the course. The teaching faculty was represented by international speakers and trainers: Serhat Bor (Turkey) Prof. Giuseppe Chiarioni (Italy), Edoardo V. Savarino (Italy) Radu Tutuian (Swiss), and also local faculty: Dan Lucian Dumitrascu, Vasile Drug, Teodora Surdea-Blaga , Ion Bancila.
The hands-on course was a great time for intellectual interaction, international collaboration and last but not least, for friendship.
Vasile Drug - May 2019
A lively 31th Anniversary Meeting of Scandinavian Association of Neurogastroenterology and Motility (SAGIM) was held at Tivoli Hotel the 23th November. More than 40 participants and business partners attended the meeting. We hosted this inspirational meeting with financial help from the sponsors. Meqnordic, Synmed, Kebomed and Grünenthal.
This year’s hot topics in upper and lower neurogastroenterology and motility were presented by speakers from all over the world; Peter Paine from London gave us an overview in treating functional pain, Magnus Simrén (Gothenburg) took us through gastroparesis and a case story. Furthermore, new subtle devices for treating and investigating the gastrointestinal tract were presented by Hans Gregersen (Hong Kong) and Ram Dickman (Petach Tikva). Also other exciting topics as fMR and IBS, reflux and management of enteric neuropathy (Greger Lindberg, Stockholm and Niels Qvist, Odense) were presented, and this also included a lot of other Scandinavian speakers.
A PhD network meeting before the meeting was introduced as a new initiative. Seven PhD students participated and the network day was successful. Next year the PhD network meeting will also be held the day before the SAGIM meeting scheduled November 22th, 2019.
Like the tradition prescribes this meeting was a great time for intellectual interactions, network,, new investigator collaborations and last but not least - for friendship.
M. Winther Andersen - March 2019
The Dutch Neurogastroenterology and Motility Society is a section of the Dutch Society of Gastroenterology (NVGE). March 20-21 the section held its yearly abstract session during NVGE’s ‘Digestive Disease Days’ at Veldhoven (The Netherlands). During these sessions we aim to bring forward a cross section of all clinical and basic NGM research that is being performed in the Netherlands. In line with our tradition to give room for young talent, all abstracts were presented by PhD students. The selected abstracts covered a wide diversity of subjects ranging from translational to purely clinical research, and from microbiome investigations to smart phone applications for symptom assessment. The abstract of Isabelle van Thiel (Tytgat Institute, Amsterdam UMC) was chosen best basic research abstract of the overall 2019 ‘Digestive Disease Days’. She presented her abstract entitled ‘Miltefosine decreases visceral hypersensitivity through modulation of the gut microbiome and mycobiome in a rodent model of Irritable Bowel Syndrome’ during the president select session of the NVGE (see graphical abstract).
René van den Wijngaard - March 2019.
The annual meeting of the Israeli gastroenterological society recently took place in Tel Aviv (16-18/1/19). During the meeting a number of plenary sessions were devoted to the field of neurogastroenterology.
The first session was focused on pelvic floor disorders form diagnosis to treatment, including talks on biofeedback and the Israeli experience in sacral nerve stimulation. Another session was dedicated to esophageal disorders and included invited lectures on GERD and PPI by Prof Ronnie Fass from the United states, and about the diagnostic and therapeutic approach to oropharyngeal dysphagia by Prof Natalie Rommel from Belgium. Another invited lecture on the pathophysiology and management of GERD was given by Prof Carmelo Scarpignato from Italy.
Additionally a number of abstracts in the field of were also presented as oral presentations.
R. Dickman - January 2019
More than 80 delegates attended the 2019 Symposium on Hypercontractile Disorders held in Pisa, March 2nd, 2019. The Symposium followed the SINGEM National Congress that involved more than 150 participants.
The Symposium was endorsed by the European Society of Neurogastroenterology and Motility (ESNM). Several distinguished speakers were invited from US and Europe, including Prakash Gyawali, Daniel Sifrim, John Pandolfino, Sabine Roman, Radu Tutuian among them. They provided outstanding lectures on the pathophysiological and clinical significance of Hypercontractile Motility Disorders as diagnosed by High Resolution Manometry applying the Chicago Classification. Moreover, they interact with the audience in order to improve our understanding of these motor disorders and to ameliorate the management of our patients. This was a unique opportunity to discuss the most controversial clinical issues in this area of neurogastroenterology and motility and to receive an update both on the more recent research and clinical data in the field!
A special thank to Medtronic, Reckitt Benckiser, Laboria and Diversatek that made it possible!
E. Savarino, R. Penagini, N. de Bortoli - March 2019
MRI analysis of fecal volume and dryness: Validation study using an experimental oxycodone‐induced constipation model (Click here for full paper)
Graphical abstracts have become more popular recently and ESNM also want to promote this way of a fast appetizer to research data. It need not to be final versions, preliminary data such as used in abstracts may also be of relevance. This abstracts from Anne-Marie Wegeberg in Denmark shows how it can be done with preliminary data from a study in diabetic neuropathy, where the the gastric pH associates to different symptoms frequently reported by these patients.
Click here to read the abstract
This year’s Little Brain Big Brain (LBBB) meeting was held a Schloss Gnadenthal, near Kleve in northern Germany between the 26th and 29th August. The LBBB meeting is a biennial meeting of young investigators interested in neurogastroenterology. 34 participants discussed a wide range of preclinical and clinical research projects around the microbiota-gut-brain axis, from the motility in zebrafish, via the development of patient-derived gut organoids, to the patient experience of anti-emetic therapies. Our award winning presentation, delivered by Constanza Alcaino, described the mechanism of 5-HT release from enterochromaffin cells in response to mechanical stimulation. Discussions went on long into the night on the methodology of sampling the dolphin microbiome. We would like to thank the national and international societies and industry sponsors, particularly the ESNM, ANMS and Takeda, for their generous support of this meeting. Little Brian, the Blue Monkey mascot of LBBB, has been passed onto the Australian organising committee, and we are convinced they will keep the spirit of LBBB alive at the XVIth meeting.
The XVth LBBB Organising committee-
Barbara Voussen, Roeland Buckinx, Nazar Mazurak, John Broad
The Spanish Society of Neurogastroenterology and Motility celebrated their annual meeting in Madrid, the 23th and 24th November. The meeting was preceded by the VIII Course of Neurogastroenterology and Motility for trainees in gastroenterology, from Thursday November 22 to Friday November 23. The course reviewed in an intensive program the most important functional and motility disorders, from the oro-pharinx to the ano-rectum, with a faculty of national experts in each field. The course was well attended with all the 85 available places reserved in advance.
The meeting of the Society started immediately after the postgraduate course with a program that combined symposia, presentations of original research, and discussion of clinical cases. The faculty included Spanish as well as international experts. Specifically this year, Frank Zerbib and Edoardo Savarino participated in a symposium on reflux disease that focused in the role of pH-measurements and pH-Impedance in the diagnosis of GERD. Roberto Di Giorgio participated together with Anna Accarino and Marcel Jimenez in a symposium on chronic intestinal pseudoobstruction, probably the most serious, but fortunately low prevalent, motility disorder. 182 delegates assisted the meeting generating lively and interesting discussions following the different presentations.
During the meeting took place the annual general assembly of the Society and the new steering committee was elected, with Dr Anna Accarino from University Hospital Vall d’Hebron in Barcelona elected as new President of the Society for the next 4 years, and the leaving SC with the President Dr. Constanza Ciriza were acknowledged for an excellent work for the Society during the past 4 years.
J. Serra - December 2018
The First European Conference for Young Gastroenterologists took place in December 2018 in Zagreb, Croatia. This congress was successful both in terms of the scientific and social program.
There were around 500 participants from all around Europe and also from Egypt, Australia, Mongolia, Korea and Morocco. The program was scheduled according to the Blue Book and covered a variety of topics including some that are not usually discussed at UEG or ESNM meetings. The lecturers were in the format of pair-talks of both renowned senior and junior gastroenterologists. The audience liked the format, and this helped them to interact easily with the faculty. Moreover, it was unique opportunity for the young doctors to actively take a part and give a lecture on an international level.
UEG was well presented at the meeting with many UEG governing members. Luigi Ricciardiello (NSC chair), Heinz Hammer (Education Committee chair), Nurdan Tözün (Chair Equality & Diversity Task Force) and Michael Manns (past –UEG president) were present. ESNM was also very well represented through Steering Committee members: Daniel Pohl, Fernado Azpiroz, Serhat Bohr, Adam Farmer and Goran Hauser. Our session was well attended and both senior and young doctors gave interesting lectures: FGID perspective (A. Farmer), gut microbiota (F. Azpiroz), oesophageal motility disorders (S. Bohr), chronic idiopatic constipation (D. Pohl) and IBS & obesity (G. Hauser).
Once again, congratulations to the local organizing committee and thanks to the Organizing Committee who invited ESNM to take part at the 1st European Young Gastro Conference, Zagreb 2018.
G. Hauser - December 2018
ESNM has been reorganized with a new treasurer to replace Paul Enck, two new members and the well known, highly appreciated and experienced President Giovanni Barbara was re-elected for another term. The treasurer is Daniel Pohl, Head of the Functional Diagnostics Center at University Hospital Zurich. Daniel is also President of the Swiss Society of Neurogastroenterology and Motility with an interest in disorders of the brain-gut axis, nutritional intolerances and upper gut motility disorders.
Dr. Olga Storonova is the group leader in Neurogastroenterological Laboratory Unit at the Moscow Sechenov University - the reference center for the study of the GI motility disorders in Russia and the principal training centre for oesophageal HRM and 24-hour pH-impedance monitoring. René van den Wijngaard is a basic scientist from Department of Gastroenterology and Hepatology/Tytgat Institute of the Amsterdam UMC. His current research interests are mainly abdominal pain complaints in the irritable bowel syndrome, and the possible role of gut fungi as a trigger for mast cell activation and subsequent visceral hypersensitivity.
On Saturday, June 30th, 25 medical professionals from all over Switzerland participated in the first SwissNGM practical motility course, planned by local organizer Dr. Lenglinger, Bern and PD Dr. Pohl, President SwissNGM.
An interactive program had been developed, alternating between “state of the art” motility talks on upper gastrointestinal function and practical teaching sessions on individual cases with personalized laptops per participant, supported by dedicated tutors from centers across the country. The faculty of internationally renowned experts Dr. Lenglinger, Prof. Fox, Prof. Tutuian and PD Dr. Pohl educated participants about basics but also new developments in the evaluation of esophageal dysfunction, specifically GERD and esophageal dysmotility, employing HRM, 24h-MIIpH and EndoFLIP.
The good atmosphere and the active participation of all involved made this day a very good and successful experience. Following this inaugural motility course, the first of its kind in Switzerland, we will repeat this course from now on every two years. The 2nd SwissNGM motility course will take place in the Romandie in June 2020.
Daniel Pohl, September 2018
On July 1-2, 2018 the annual retreat of the Interdisciplinary Center for Neuroscience of the University of Heidelberg (IZN) took place at the monastery Schöntal. 146 people from 37 IZN Research Groups including 35 Major Neuroscience students from Heidelberg attended. The event was sponsored by the SFB1134, the German Society of Neurogastroenterology and Motility (DGNM) and endorsed by the European Society of Neurogastroenterology and Motility (ESNM). This was the first IZN Retreat dedicated to neurogastroenterology and the gut brain axis organised by Beate Niesler, IZN Principle Investigator since 2017.
On Sunday July 1, the IZN Retreat was opened by the IZN Director Hilmar Bading giving an introduction and update on the IZN, its activities and the program of the retreat. The first speaker Michael Schemann from the TUM Munich, Germany, gave an excellent introduction into the ENS and its function. This was followed by a talk of Vassilis Pachnis form the The Francis Crick Institute in London, UK, who focussed on the development of the ENS and shared latest research data. After a nice and sunny open air lunch within the monastery garden, one had the opportunity to attend a guided tour of the monastery, stroll a bit around or go on a canoe tour on the river Jagst. Everyone met again for an open air dinner and the evening lecture was given by Emeran Mayer from the UCLA, Los Angeles USA, who reported on the paradigm shift in neuroscience based on recent research data of the microbiota gut brain axis. After an outstanding talk and a lively discussion, everyone gathered for drinks and the poster session where 44 posters were presented by young investigators.
On Monday morning the meeting went on with a talk by Beate Niesler, IZN Heidelberg, on dissecting the genetics of a prototypical gut brain disorder: irritable bowel syndrome and introducing GENIEUR, the Genes in Irritable Bowel Syndrome Research Network Europe. Lukas van Oudenhove from the KU Leuven, Belgium, gave insight into brain imaging and assessing gut brain disorders relevant brain structure, circuits and function. Discussions went on during the coffee break and later on Stefanie Kürten from the University of Erlangen reported on gastrointestinal changes within CNS disorders with a focus on Multiple Sclerosis. Lunch was served at 13:00 after the PI meeting and PhD meeting.
Within the afternoon session, new IZN members, all Chica and Heinz Schaller Research Group Leaders, gave insights into their research topics: Annarita Patrizi, Amid Agarwal and Claudio Acuno. This was followed by the IZN award ceremony. The IZN-Students Poster Prize was awarded to Diego Benusiglio of Valery Grinevich’s team for his poster entitled: ‘Sensory-driven activation of oxytocin neurons during social interaction’. The Foundation BrainAid IZN Master’s Award 2018 was given to
Melina Castelanelli for her Master Thesis on ‘Evaluation of neuronal optogenetic manipulation in
vitro and in freely moving mice’. Last not least, the IZN / Chica and Heinz Schaller Young Investigator Neuroscience Award was handed over to Max Richter, PhD student of Ulrike Müller, the thesis of whom was published in the EMBO Journal.
In conclusion, this was a timely event that was highly appreciated and rated as outstanding by Hilmar Bading within his concluding remarks. He furthermore encouraged the master students to step into the area of gut brain disorders. We are looking forward to building upon this first gut brain axis event and developing this research area further in Heidelberg.
Beate Niesler - July 2018
Research Group Genetics in Neurogastroenterologic Disorders within the IZN Heidelberg
Lee Swanstrom, surgeon, promoted POEM and stated that this technique already reached 10 years of clinical experience (7000 cases) with hundreds of publications. According to his experience and according to a metaanalysis, Heller myotomy and POEM are equivalent in regard to complications, relief of dysphagia (Eckardt Score) and GERD. In contrary, Peter Kahrilas promoted dilation, demonstrating that dilation of Type 2 is very successful (95-100%) and that according to the European Achalasia Trial (2011, first 2 years) dilation was found to be as effective as Heller and that the dilation’s protocol (aggressive vs. not-aggressive) may impact the success of dilation. Peter mentioned the POEMA Trial (Abstract form) that compared a less aggressive protocol of dilation and POEM, showing a lower success rate for dilation (54% vs. 92%, respectively). Finally, Peter presented a comparison between Dilation and POEM based on medical literature and demonstrated that there is “more GERD” in the POEM group.
The Moderator, David Katzka, admitted that both are good choices with relative benefits and risks (he added adhesions from POEM…) and overall, was in favor of dilation and not of POEM!
From the audience: Guy Boeckxstaens raised the question whether POEM provokes esophageal stenosis and Joel Richter raised the question whether POEM converts “Achalasia into Scleroderma" and this condition may be manifested as a risk factor to BE and … in 20-30 yrs.
Ram Dickman - June 2018
We are pleased to inform you that the United European Gastroenterology (UEG) approved two recent grant applications for ESNM, both on guideline development. One grant was approved for development of a guideline on achalasia (chaired by Arjan Bredenoord), another grant will allow the development of guideline for gastroparesis and functional dyspepsia (chaired by Paul Enck and Jan Tack).
Grants have a value of 40.000 € each for the next three years.
MRI detection and histological localization of transplanted neural crest derived stem cells (NCSCs) labeled with superparamagnetic nanoparticles in future perspectives for cell therapy of Hirschsprung’s disease
J Clasohm1, C Merscher1,2, A Müller2, A Braun1, D Grundmann1, P Fries2, G Schneider2, A Bücker2, KH Schäfer1,3
1 Working Group Enteric Nervous System, University of Applied Sciences Kaiserslautern, Zweibruecken, Germany
2 Department of Radiology, University of Saarland, Homburg, Germany
3 Department of Pediatric Surgery Mannheim, Medical University of Heidelberg, 68167 Mannheim, Theodor-Kutzer-Ufer 1-3, Germany
The repopulation with neurons, neuronal progenitor or stem cells is a central issue for the therapy of Hirschsprung’s disease, where patients suffer from symptoms mainly caused by the lacking intrinsic innervation of gut segments.
Transplanted stem cells can be tracked by magnetic-resonance-imaging (MRI) after incorporation of superparamagnetic nanoparticles prior to cell implantation. Until now in vivo tracking of transplanted neural crest derived stem cells for the treatment of Hirschsprung’s disease have not been performed. Here we propose a new method to follow the transplanted cells and their integration via MRI.
To do so, enteric neurospheres were generated from postnatal myenteric plexus and labeled with superparamagnetic iron oxide nanoparticles coupled GFP (Green Fluorescence Protein). These allow a combined MRI detection and fluorescence control of successful incorporation of nanoparticles (NP’s). Prior to implantation, the possibility of following the labeled cells was proofed in vitro. Here we observed the differentiation of successful labeled neurospheres using fluorescence microscopy and MRI. We could quantify the MRI measurements regarding signal density and status of neutrospheres differentiation. The signal density of nanoparticles in MRI gets lower and the signal area increases, while the background value decreases.
After implanting NP-labeled neurospheres in ex vivo gut segments, we could locate them in MRI-images and verify these data with histological sections after imaging. Frontal sections of the gut segments did confirm the MRI data.
The incorporation of magnetic nanobeads thus allows to follow the transplantation success and migration of the cells within a short time window following injection. Future experiments will show whether we might even guide or spread the cells within the tissue using electromagnetic fields.
The GMFH editing team is pleased to bring you the official report of the 2018 Gut Microbiota for Health World Summit. It covers the main take-home messages from the different sessions (plenaries and workshops) of the summit, including key conclusions on topics such as probiotics, prebiotics, gut barrier, immune health, among others.
Check out the interactive version of the report by clicking on the image and feel free to share it. We hope you enjoy the reading!
Dear ESNM Members,
it is our pleasure to announce that the first step of the Joint ANMS-ESNM task force being created with Prakash Gyawali (ANMS) and Edoardo Savarino (ESNM) as co-chairs have completed the first part of its work and produced a Curriculum, with different subdomains sub-divided in three tiers according to different degree of expertise, for physicians who are going to increase their knowledge in Neurogastroenterology and, perhaps, developing a future career in this field. The curriculum has been submitted and accepted for publication in our Journal, Neurogastroenterology and Motility, and will be presented at the upcoming Federation of Neurogastroenterology and Motility Congress in Amsterdam (August 2018). The next steps of the Joint ANMS-ESNM task force will be to develop criteria to assess quality of academic NGM centers, utilizing curriculum and training domains from this recent publication.
Edoardo Savarino - March 2018
Click here to read the curriculum
It is becoming increasingly evident that bidirectional signalling exists between the gastrointestinal tract and the brain, often involving the gut microbiota. This relationship, commonly dubbed the gut–brain axis (or the microbiota–gut–brain axis), involves various afferent and efferent pathways such as the vagus nerve and the hypothalamic-pituitary-adrenal pathway to regulate aspects of homeostasis such as satiety and hunger, and inflammation. Disruption of the gut–brain axis has been shown to be involved in the pathogenesis of a diverse range of diseases, including Parkinson disease and irritable bowel syndrome. This emerging area of research is evolving quickly.
For the ful collection by nature.com click here
Articles in the core collection have been made freely available for 6 months (until 11th July 2018)
· January 2017
The Semi-annual meeting of the Israel Gastroenterology Association
o Rome Foundation Symposium with Drs. Drossman, Simren, and Sperber
o Sessions on NeuroGI issues with Drs. Tack, Simren, Sifrim, Fass
o Workshop on Guidelines for the Treatment of GERD
· June 2017
Semi-annual meeting of Israel Gastroenterology Association
o Formulation of Guidelines for Manometry and pH-testing reports (with Dr. Sifrim)
o Lectures on IBS and GERD and a debate on the use of breath tests in the framework of “Choosing Wisely”
· Formulation of guidelines for the treatment of chronic constipation.
· Ongoing lectures to family doctors on GERD, constipation, gastroparesis, ENT issues as part of their CME programs
· Ongoing lectures to nurses specializing in diabetes and to endocrinologists on GI complications in diabetic patients as part of their CME programs
· The society is active in the attempt to include new drugs and technologies related to neuroGI in the Israeli basket of health services.
· Implementation of formal NeuroGI curricula for medical students in the Israeli medical schools.
· The chair, Prof. Dickman is active on the steering committee of the ESNM including preparation of the meeting in August 2017 in Cork, Ireland.
· The chair, Prof. Dickman is active on the committee for writing the syllabus for training in NeuroGI of the ASNM.
· The society is working actively with ESNM to foster collaborations with pharmaceutical companies to advance multicenter research, for example on gastroparesis.
· Young neuroGI doctors were sent to the workshop on manometry and pH testing in Izmir Turkey (directed by Dr. Bor) and will be sent to the workshop in Cluj Romania (Dr. Dumitrascu) in 2018.
· The society maintains a website for doctors and patients and conducts an Internet forum for joint consultation on complex clinical cases.
· Prof. Sperber is on the Board of Directors of the Rome Foundation, is the chair of the RF global survey of FGID epidemiology and has lectured in 2017 in meetings in Israel, Japan, the USA, Ireland, and India.
· Members of the society have published scientific papers in the medical literature and presented abstracts (oral and poster) at scientific meetings around the world.
· MJanuary 10-12, 2018 The Israeli Gastroenterology Assocaition had is biannual conference in Tgel Aviv, Israel, the Israeli Group of Neurogastroenterology was involved with 3 sessions
Ram Dickman - February 2018
The Italian Society of Neurogastroenterology and Motility (SINGEM) (originally GISMAD: Gruppo Italiano per lo Studio della Motilità dell’Apparato Digerente) was founded in 1983 during its first national meeting which was held in Bologna to gather investigators with a specific interest in physiological and pathophysiological aspects of esophageal, gastric, intestinal and colorectal motility patterns. Since then national meetings have been regularly organized every other year:
I Bologna - Novembre 1983
II Genova - Marzo 1986
III Cortina D’Ampezzo (Bl) - Gennaio 1988
IV Sirmione (Bs)- Aprile 1990
V Marina di Ravenna (Ra) - Luglio 1992
V I Sorrento - Settembre 1994
V II Perugia - Giugno 1996
V III St. Vincent - Febbraio 1999
IX Milano Marittima ( Ra) - Settembre 2000
X Marina di Ostuni( Br) - Maggio 2002
XI Palermo - Ottobre 2004
XII Gardone Riviera (Bs) - Aprile 2007
XIII Napoli - Settembre 2008
XIV Venezia-Mestre- Marzo 2011
XV Firenze, Aprile 2013
XVI Roma, 7-9 Maggio 2015
XVII Milano, 9-11 Marzo 2017
Over the years the interests of the society have expanded beyond GI motility to embrace all aspects of current Neurogastroenterology, thus attracting an increasing number of gastroenterologists, surgeons, biologists, pharmacologists, leading to the actual number of 196 active members.
In addition to the biannual national meeting, SINGEM implemented other scientific and educational events in Italy: hands-on courses designed to diffuse manometry and pH-metry skills among young Italian investigators collaborative studies among Centers with common interests, organization of and collaboration with groups of patients with different neurogastroenterological
diseases including achalasia and chronic intestinal pseudo-obstruction.
The 17th SINGEM meeting organized in Milan was preceded, according to an established tradition, by a practical course, with 80 trainees in Gastroenterology participating, while 200 registered delegates participated in the core meeting with a scientific program including 5 invited lectures, 9 oral presentations and 35 posters. Young investigators awards were distributed.
Due to recently introduced requirements of the Italian Ministry of Health for a Scientific Society to be officially acknowledged as such, the original statute of GISMAD has been updated and the opportunity was taken to change the original name into SINGEM. At the same time the website of the society is also undergoing a major renewal and can be reached at the address www.singem.it.
SINGEM is proudly an active member of ESNM
Giovanni Barbara - March 2018
Sixty-five participants from different disciplines gathered at the Palotti Haus in Freising at the occasion of the 25th annual meeting of the German Society of Neurogastronenterology and Motility (DGNM) from March 2-4, 2018. The meeting started on Friday afternoon with a dinner followed by a get together party. Saturday morning F. Reimann from Cambridge (UK) gave a state of the art lecture on nutrient sensing by enteroendocrine cells in the intestine.
During the 25th anniversary meeting, 33 talks were given in eight sessions. These were dedicated to basic science (ENS, translational – food intake stress, motility, inflammation, methods, ENS, microbiome, probiotics, pancreas) and clinical science (motility and diverticular disease) and given by mainly youngsters who reported on their ongoing projects. A highlight was the lecture given by Peter Neckel from Tübingen on tissue clearing in neurogastroenterology who had received the DGVS Research Award of the Neurogastroenterology Foundation in 2017.
At the general assembly on Saturday evening, members of the society were updated on the activities of the national and international societies. In addition, Beate Niesler gave a progress report on GENIEUR, the UEG-LINK project Help EU in IBS, and actual ESNM activities. Furthermore, she encouraged people to attend a retreat at Kloster Schöntal entitled Gut Brain Axis in Health and Diseases that she organized within the frame of the Heidelberg Center of Interdisciplinary Neuroscience. Martha Anna Schalla from Berlin and Stefanie Schmitteckert from Heidelberg were awarded with Martin Wienbeck Travel Grants.
After the Sunday lectures the meeting was concluded with a common lunch. The next meeting will take place in Berlin on March 22-24, 2019
Beate Niesler - March 2018
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