ESNM News

Graphical abstracts have become more popular recently and ESNM also want to promote this way of a fast appetizer to research data. It need not to be final versions, preliminary data such as used in abstracts may also be of relevance. This abstracts from Anne-Marie Wegeberg in Denmark shows how it can be done with preliminary data from a study in diabetic neuropathy, where the the gastric pH associates to different symptoms frequently reported by these patients.
Click here to read the abstract 

nEUROgastro TANDEM 2019 - Deadline approaching

The 3rd edition of this novel type of young investigator meeting will take place in Lisbon (Portugal) from September 2nd-4th, 2019, just prior to ESNM meeting. The competitive application forum will be open until January 15th and can be accessed via the homepage: http://gastrotandem.jimdo.com/upcoming-meeting/, where some impressions of the previous meeting in Cork 2017 can be found as well.

Application is highly recommended to European young physicians and scientists currently working or interested in the field of neurogastroenterology and motility. Explicitly invited are the European participants of the Little Brain Big Brain meeting that was held in Kleve, Germany this year.

Step up to shape the future of neurogastroenterology and motility by being part of nEUROgastroTANDEM 2019.

The XVth Little Brain Big Brain Meeting, 2018

The Prize winners: K. Hamilton, M. Mahe, C. Alcaino
Ceremonial handover of Little Brian L. Grundy, L. Stamp, J. Foong, M. (and Isobel) Hao, N. Mazurak, J. Broad, R. Buckinx
The LBBB 2018 attendees

This year’s Little Brain Big Brain (LBBB) meeting was held a Schloss Gnadenthal, near Kleve in northern Germany between the 26th and 29th August. The LBBB meeting is a biennial meeting of young investigators interested in neurogastroenterology. 34 participants discussed a wide range of preclinical and clinical research projects around the microbiota-gut-brain axis, from the motility of zebrafish, to the development of patient-derived gut organoids, to the patient experience of anti-emetic therapies. Our award winning presentation, delivered by Constanza Alcaino, described the mechanism of 5-HT release from enterochromaffin cells in response to mechanical stimulation. Discussions went on long into the night on the methodology of sampling the dolphin microbiome. We would like to thank the national and international societies and industry sponsors, particularly the ESNM, ANMS and Takeda, for their generous support of this meeting. Little Brian, the Blue Monkey mascot of LBBB, has been passed onto the Australian organising committee, and we are convinced they will keep the spirit of LBBB alive at the XVIth meeting.  

The XVth LBBB Organising committee-
Barbara Voussen, Roeland Buckinx, Nazar Mazurak, John Broad

 

 

XXVI Meeting of the Sanisch Society of Neurogastroenterology and Motility (GEMD)

The Spanish Society of Neurogastroenterology and Motility celebrated their annual meeting in Madrid, the 23th and 24th November. The meeting was preceded by the VIII Course of Neurogastroenterology and motility for trainees in gastroenterology, from Thursday November 22 to Friday November 23. The course reviewed in an intensive program the most important functional and motility disorders, from the oro-pharinx to the ano-rectum, with a faculty of national experts in each field. The course was well attended with all the 85 available places reserved in advance.

The meeting of the Society started immediately after the postgraduate course with a program that combined symposia, presentations of original research, and discussion of clinical cases. The faculty included Spanish as well as international experts. Specifically this year, Frank Zerbib and Edoardo Savarino participated in a symposium on reflux disease that focused in the role of pH-measurements and pH-Impedance in the diagnosis of GERD. Roberto Di Giorgio participated together with Anna Accarino and Marcel Jimenez in a symposium on chronic intestinal pseudoobstruction, probably the most serious, but fortunately low prevalent, motility disorder.  182 delegates assisted the meeting generating lively and interesting discussions following the different presentations.

During the meeting took place the annual general assembly of the Society and the new steering committee was elected, with Dr Anna Accarino from University Hospital Vall d’Hebron in Barcelona elected as new President of the Society for the next 4 years, and the leaving SC with the President Dr. Constanza Ciriza were acknowledged for an excellent work for the Society during the past 4 years.

J. Serra - December 2018

Re-election and Replacements in the Steeing Committee

ESNM Steering Committee 2018
D.Pohl and G. Barbara
O. Storonova and R. vd Wijngaard

ESNM has been reorganized with a new treasurer to replace Paul Enck, two new members and the well known, highly appreciated and experienced President Giovanni Barbara was re-elected for another term. The treasurer is Daniel Pohl, Head of the Functional Diagnostics Center at University Hospital Zurich. Daniel is also President of the Swiss Society of Neurogastroenterology and Motility with an interest in disorders of the brain-gut axis, nutritional intolerances and upper gut motility disorders.

Dr. Olga Storonova is the group leader in Neurogastroenterological Laboratory Unit at the Moscow Sechenov University - the reference center for the study of the GI motility disorders in Russia and the principal training centre for oesophageal HRM and 24-hour pH-impedance monitoring. René van den Wijngaard is a basic scientist from Department of Gastroenterology and Hepatology/Tytgat Institute of the Amsterdam UMC. His current research interests are mainly abdominal pain complaints in the irritable bowel syndrome, and the possible role of gut fungi as a trigger for mast cell activation and subsequent visceral hypersensitivity.

AM Drewes

 

 

Practical Motility Day – Impressions - an ESNM endorsed Event

On Saturday, June 30th, 25 medical professionals from all over Switzerland participated in the first SwissNGM practical motility course, planned by local organizer Dr. Lenglinger, Bern and PD Dr. Pohl, President SwissNGM.

An interactive program had been developed, alternating between “state of the art” motility talks on upper gastrointestinal function and practical teaching sessions on individual cases with personalized laptops per participant, supported by dedicated tutors from centers across the country. The faculty of internationally renowned experts Dr. Lenglinger, Prof. Fox, Prof. Tutuian and PD Dr. Pohl educated participants about basics but also new developments in the evaluation of esophageal dysfunction, specifically GERD and esophageal dysmotility, employing HRM, 24h-MIIpH and EndoFLIP.

The good atmosphere and the active participation of all involved made this day a very good and successful experience. Following this inaugural motility course, the first of its kind in Switzerland, we will repeat this course from now on every two years. The 2nd SwissNGM motility course will take place in the Romandie in June 2020.

 

Daniel Pohl, September 2018

IZN Retreat 2018 The gut brain axis in health and disease – an ESNM endorsed event

On July 1-2, 2018 the annual retreat of the Interdisciplinary Center for Neuroscience of the University of Heidelberg (IZN) took place at the monastery Schöntal. 146 people from 37 IZN Research Groups including 35 Major Neuroscience students from Heidelberg attended. The event was sponsored by the SFB1134, the German Society of Neurogastroenterology and Motility (DGNM) and endorsed by the European Society of Neurogastroenterology and Motility (ESNM). This was the first IZN Retreat dedicated to neurogastroenterology and the gut brain axis organised by Beate Niesler, IZN Principle Investigator since 2017.

On Sunday July 1, the IZN Retreat was opened by the IZN Director Hilmar Bading giving an introduction and update on the IZN, its activities and the program of the retreat. The first speaker Michael Schemann from the TUM Munich, Germany, gave an excellent introduction into the ENS and its function. This was followed by a talk of Vassilis Pachnis form the The Francis Crick Institute in London, UK, who focussed on the development of the ENS and shared latest research data. After a nice and sunny open air lunch within the monastery garden, one had the opportunity to attend a guided tour of the monastery, stroll a bit around or go on a canoe tour on the river Jagst. Everyone met again for an open air dinner and the evening lecture was given by Emeran Mayer from the UCLA, Los Angeles USA, who reported on the paradigm shift in neuroscience based on recent research data of the microbiota gut brain axis. After an outstanding talk and a lively discussion, everyone gathered for drinks and the poster session where 44 posters were presented by young investigators.

On Monday morning the meeting went on with a talk by Beate Niesler, IZN Heidelberg, on dissecting the genetics of a prototypical gut brain disorder: irritable bowel syndrome and introducing GENIEUR, the Genes in Irritable Bowel Syndrome Research Network Europe. Lukas van Oudenhove from the KU Leuven, Belgium, gave insight into brain imaging and assessing gut brain disorders relevant brain structure, circuits and function. Discussions went on during the coffee break and later on Stefanie Kürten from the University of Erlangen reported on gastrointestinal changes within CNS disorders with a focus on Multiple Sclerosis. Lunch was served at 13:00 after the PI meeting and PhD meeting.

Within the afternoon session, new IZN members, all Chica and Heinz Schaller Research Group Leaders, gave insights into their research topics: Annarita Patrizi, Amid Agarwal and Claudio Acuno. This was followed by the IZN award ceremony. The IZN-Students Poster Prize was awarded to Diego Benusiglio of Valery Grinevich’s team for his poster entitled: ‘Sensory-driven activation of oxytocin neurons during social interaction’. The Foundation BrainAid IZN Master’s Award 2018 was given to
Melina Castelanelli for her Master Thesis on ‘Evaluation of neuronal optogenetic manipulation in
vitro and in freely moving mice’. Last not least, the IZN / Chica and Heinz Schaller Young Investigator Neuroscience Award was handed over to Max Richter, PhD student of Ulrike Müller, the thesis of whom was published in the  EMBO Journal.

In conclusion, this was a timely event that was highly appreciated and rated as outstanding by Hilmar Bading within his concluding remarks. He furthermore encouraged the master students to step into the area of gut brain disorders. We are looking forward to building upon this first gut brain axis event and developing this research area further in Heidelberg.

Beate Niesler - July 2018
Research Group Genetics in Neurogastroenterologic Disorders within the IZN Heidelberg

DDW 2018 Debate! To POEM or not to POEM?

Lee Swanstrom, surgeon, promoted POEM and stated that this technique already reached 10 years of clinical experience (7000 cases) with hundreds of publications. According to his experience and according to a metaanalysis, Heller myotomy and POEM are equivalent in regard to complications, relief of dysphagia (Eckardt Score) and GERD. In contrary, Peter Kahrilas promoted dilation, demonstrating that dilation of Type 2 is very successful (95-100%) and that according to the European Achalasia Trial (2011, first 2 years) dilation was found to be as effective as Heller and that the dilation’s protocol (aggressive vs. not-aggressive) may impact the success of dilation. Peter mentioned the POEMA Trial (Abstract form) that compared a less aggressive protocol of dilation and POEM, showing a lower success rate for dilation (54% vs. 92%, respectively). Finally, Peter presented a comparison between Dilation and POEM based on medical literature and demonstrated that there is “more GERD” in the POEM group.

The Moderator, David Katzka, admitted that both are good choices with relative benefits and risks (he added adhesions from POEM…) and overall, was in favor of dilation and not of POEM!

From the audience: Guy Boeckxstaens raised the question whether POEM provokes esophageal stenosis and Joel Richter raised the question whether POEM converts “Achalasia into Scleroderma" and this condition may be manifested as a risk factor to BE and … in 20-30 yrs.

Ram Dickman - June 2018

We are pleased to inform you that the United European Gastroenterology (UEG) approved two recent grant applications for ESNM, both on guideline development. One grant was approved for development of a guideline on achalasia (chaired by Arjan Bredenoord), another grant will allow the development of guideline for gastroparesis and functional dyspepsia (chaired by Paul Enck and Jan Tack).
Grants have a value of 40.000 € each for the next three years. 


Figure 1: A T2-RARE MRI imaging of gut segment before and after implantation of nanoparticle labeled enteric neurospheres. Scale bar 3 mm. B T2 weighted RARE MRI sequences of whole mount samples 24 hrs and 72 hrs after implantation of nanoparticle labeled enteric neurospheres. Scale bar 5 mm. C Whole mount 72 hrs, post implantation of GFP labeled cells. Scale bar 16 µm.

 

MRI detection and histological localization of transplanted neural crest derived stem cells (NCSCs) labeled with superparamagnetic nanoparticles in future perspectives for cell therapy of Hirschsprung’s disease

J Clasohm1, C Merscher1,2, A Müller2, A Braun1, D Grundmann1, P Fries2, G Schneider2, A Bücker2, KH Schäfer1,3

1 Working Group Enteric Nervous System, University of Applied Sciences Kaiserslautern, Zweibruecken, Germany

2 Department of Radiology, University of Saarland, Homburg, Germany

3 Department of Pediatric Surgery Mannheim, Medical University of Heidelberg, 68167 Mannheim, Theodor-Kutzer-Ufer 1-3, Germany

Abstract:

The repopulation with neurons, neuronal progenitor or stem cells is a central issue for the therapy of Hirschsprung’s disease, where patients suffer from symptoms mainly caused by the lacking intrinsic innervation of gut segments.

Transplanted stem cells can be tracked by magnetic-resonance-imaging (MRI) after incorporation of superparamagnetic nanoparticles prior to cell implantation. Until now in vivo tracking of transplanted neural crest derived stem cells for the treatment of Hirschsprung’s disease have not been performed. Here we propose a new method to follow the transplanted cells and their integration via MRI.

To do so, enteric neurospheres were generated from postnatal myenteric plexus and labeled with superparamagnetic iron oxide nanoparticles coupled GFP (Green Fluorescence Protein). These allow a combined MRI detection and fluorescence control of successful incorporation of nanoparticles (NP’s). Prior to implantation, the possibility of following the labeled cells was proofed in vitro. Here we observed the differentiation of successful labeled neurospheres using fluorescence microscopy and MRI. We could quantify the MRI measurements regarding signal density and status of neutrospheres differentiation. The signal density of nanoparticles in MRI gets lower and the signal area increases, while the background value decreases.

After implanting NP-labeled neurospheres in ex vivo gut segments, we could locate them in MRI-images and verify these data with histological sections after imaging. Frontal sections of the gut segments did confirm the MRI data.

The incorporation of magnetic nanobeads thus allows to follow the transplantation success and migration of the cells within a short time window following injection.  Future experiments will show whether we might even guide or spread the cells within the tissue using electromagnetic fields.

J. Clasohm

Click here for Abstracts NeuroGASTRO 2017

The GMFH editing team is pleased to bring you the official report of the 2018 Gut Microbiota for Health World Summit. It covers the main take-home messages from the different sessions (plenaries and workshops) of the summit, including key conclusions on topics such as probiotics, prebiotics, gut barrier, immune health, among others.

Check out the interactive version of the report by clicking on the image and feel free to share it. We hope you enjoy the reading!

Dear ESNM Members,

it is our pleasure to announce that the first step of the Joint ANMS-ESNM task force being created with Prakash Gyawali (ANMS) and Edoardo Savarino (ESNM) as co-chairs have completed the first part of its work and produced a Curriculum, with different subdomains sub-divided in three tiers according to different degree of expertise, for physicians who are going to increase their knowledge in Neurogastroenterology and, perhaps, developing a future career in this field. The curriculum has been submitted and accepted for publication in our Journal, Neurogastroenterology and Motility, and will be presented at the upcoming Federation of Neurogastroenterology and Motility Congress in Amsterdam (August 2018). The next steps of the Joint ANMS-ESNM task force will be to develop criteria to assess quality of academic NGM centers, utilizing curriculum and training domains from this recent publication.

Edoardo Savarino - March 2018
Click here to read the curriculum

It is becoming increasingly evident that bidirectional signalling exists between the gastrointestinal tract and the brain, often involving the gut microbiota. This relationship, commonly dubbed the gut–brain axis (or the microbiota–gut–brain axis), involves various afferent and efferent pathways such as the vagus nerve and the hypothalamic-pituitary-adrenal pathway to regulate aspects of homeostasis such as satiety and hunger, and inflammation. Disruption of the gut–brain axis has been shown to be involved in the pathogenesis of a diverse range of diseases, including Parkinson disease and irritable bowel syndrome. This emerging area of research is evolving quickly.

For the ful collection by nature.com click here

Articles in the core collection have been made freely available for 6 months (until 11th July 2018)

Society News: Israeli Group of Neurogastroenterology

·         January 2017
The Semi-annual meeting of the Israel Gastroenterology Association

o   Rome Foundation Symposium with Drs. Drossman, Simren, and Sperber

o   Sessions on NeuroGI issues with Drs. Tack, Simren, Sifrim, Fass

o   Workshop on Guidelines for the Treatment of GERD

·        June 2017
Semi-annual meeting of Israel Gastroenterology Association

o   Formulation of Guidelines for Manometry and pH-testing reports (with Dr. Sifrim)

o   Lectures on IBS and GERD and a debate on the use of breath tests in the framework of “Choosing Wisely”

·         Formulation of guidelines for the treatment of chronic constipation.

·         Ongoing lectures to family doctors on GERD, constipation, gastroparesis, ENT issues as part of their CME programs

·         Ongoing lectures to nurses specializing in diabetes and to endocrinologists on GI complications in diabetic patients as part of their CME programs

·         The society is active in the attempt to include new drugs and technologies related to neuroGI in the Israeli basket of health services.

·         Implementation of formal NeuroGI curricula for medical students in the Israeli medical schools.

·         The chair, Prof. Dickman is active on the steering committee of the ESNM including preparation of the meeting in August 2017 in Cork, Ireland.

·         The chair, Prof. Dickman is active on the committee for writing the syllabus for training in NeuroGI of the ASNM.

·         The society is working actively with ESNM to foster collaborations with pharmaceutical companies to advance multicenter research, for example on gastroparesis.

·         Young neuroGI doctors were sent to the workshop on manometry and pH testing in Izmir Turkey (directed by Dr. Bor) and will be sent to the workshop in Cluj Romania (Dr. Dumitrascu) in 2018.

·         The society maintains a website for doctors and patients and conducts an Internet forum for joint consultation on complex clinical cases.

·         Prof. Sperber is on the Board of Directors of the Rome Foundation, is the chair of the RF global survey of FGID epidemiology and has lectured in 2017 in meetings in Israel, Japan, the USA, Ireland, and India.

·         Members of the society have published scientific papers in the medical literature and presented abstracts (oral and poster) at scientific meetings around the world.

·         MJanuary 10-12, 2018 The Israeli Gastroenterology Assocaition had is biannual conference in Tgel Aviv, Israel, the Israeli Group of Neurogastroenterology was involved with 3 sessions 

Ram Dickman - February 2018

Society News: 35 Years Anniversary of SINGEM

The Italian Society of Neurogastroenterology and Motility (SINGEM) (originally GISMAD: Gruppo Italiano per lo Studio della Motilità dell’Apparato Digerente) was founded in 1983 during its first national meeting which was held in Bologna to gather investigators with a specific interest in physiological and pathophysiological aspects of esophageal, gastric, intestinal and colorectal motility patterns. Since then national meetings have been regularly organized every other year:
I Bologna - Novembre 1983
II Genova - Marzo 1986
III Cortina D’Ampezzo (Bl) - Gennaio 1988
IV Sirmione (Bs)- Aprile 1990
V Marina di Ravenna (Ra) - Luglio 1992
V I Sorrento - Settembre 1994
V II Perugia - Giugno 1996
V III St. Vincent - Febbraio 1999
IX Milano Marittima ( Ra) - Settembre 2000
X Marina di Ostuni( Br) - Maggio 2002
XI Palermo - Ottobre 2004
XII Gardone Riviera (Bs) - Aprile 2007
XIII Napoli - Settembre 2008
XIV Venezia-Mestre- Marzo 2011
XV Firenze, Aprile 2013
XVI Roma, 7-9 Maggio 2015
XVII Milano, 9-11 Marzo 2017
Over the years the interests of the society have expanded beyond GI motility to embrace all aspects of current Neurogastroenterology, thus attracting an increasing number of gastroenterologists, surgeons, biologists, pharmacologists, leading to the actual number of 196 active members.
In addition to the biannual national meeting, SINGEM implemented other scientific and educational events in Italy: hands-on courses designed to diffuse manometry and pH-metry skills among young Italian investigators collaborative studies among Centers with common interests, organization of and collaboration with groups of patients with different neurogastroenterological
diseases including achalasia and chronic intestinal pseudo-obstruction.
The 17th SINGEM meeting organized in Milan was preceded, according to an established tradition, by a practical course, with 80 trainees in Gastroenterology participating, while 200 registered delegates participated in the core meeting with a scientific program including 5 invited lectures, 9 oral presentations and 35 posters. Young investigators awards were distributed.

Due to recently introduced requirements of the Italian Ministry of Health for a Scientific Society to be officially acknowledged as such, the original statute of GISMAD has been updated and the opportunity was taken to change the original name into SINGEM. At the same time the website of the society is also undergoing a major renewal and can be reached at the address www.singem.it.
SINGEM is proudly an active member of ESNM

Giovanni Barbara - March 2018

Society News: 25th annual meeting of DGNM

Sixty-five participants from different disciplines gathered at the Palotti Haus in Freising at the occasion of the 25th annual meeting of the German Society of Neurogastronenterology and Motility (DGNM) from March 2-4, 2018. The meeting started on Friday afternoon with a dinner followed by a get together party. Saturday morning F. Reimann from Cambridge (UK) gave a state of the art lecture on nutrient sensing by enteroendocrine cells in the intestine.

During the 25th anniversary meeting, 33 talks were given in eight sessions. These were dedicated to basic science (ENS, translational – food intake stress, motility, inflammation, methods, ENS, microbiome, probiotics, pancreas) and clinical science (motility and diverticular disease) and given by mainly youngsters who reported on their ongoing projects. A highlight was the lecture given by Peter Neckel from Tübingen on tissue clearing in neurogastroenterology who had received the DGVS Research Award of the Neurogastroenterology Foundation in 2017.

At the general assembly on Saturday evening, members of the society were updated on the activities of the national and international societies. In addition, Beate Niesler gave a progress report on GENIEUR, the UEG-LINK project Help EU in IBS, and actual ESNM activities. Furthermore, she encouraged people to attend a retreat at Kloster Schöntal entitled Gut Brain Axis in Health and Diseases that she organized within the frame of the Heidelberg Center of Interdisciplinary Neuroscience. Martha Anna Schalla from Berlin and Stefanie Schmitteckert from Heidelberg were awarded with Martin Wienbeck Travel Grants.

After the Sunday lectures the meeting was concluded with a common lunch. The next meeting will take place in Berlin on March 22-24, 2019

Beate Niesler - March 2018

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